ID 110866
著者
徳永, 逸夫 Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School
石上, 安希子 Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
久保, 真一 Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
後藤田, 貴子 Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School
北村, 修 Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School
キーワード
methamphetamine
neurotoxicity
peroxidative DNA damage
8-OH-dG
brain
資料タイプ
学術雑誌論文
抄録
In this study, we investigated methamphetamine (METH)- induced peroxidative DNA damage in various regions of the rat brain. We injected METH to rats following 2 protocols. For the single administration experiment (group I), 50 mg/kg (i.p.) of METH was administered to observe the acute influence of METH. For the repeated administration experiment (group II), 10 mg/kg/day (i.p.) of METH was injected for 5 days. Immunohistochemically, peroxidative damage DNA, 8-hydroxy-2’- deoxyguanosine (8-OH-dG) was observed, and in situ apoptosis was also observed. In group I, immunoreactivity of 8-OH-dG was only enhanced in neurons of the nucleus accumben of METH-treated rats. On in situ apoptosis detection, positive findings were also enhanced in all examined parts compared to those in the control, though there were no significant increases in 8-OH-dG-immunopositive neurons except in the nucleus accumben. In group II, the nucleus accumben also showed enhanced 8-OH-dG immunopositivity compared to that in the control. There was no significant difference in apoptosis between the control and METH groups. Based on our observations, it is considered that METH induces oxidative DNA damage in the brain, especially in the nucleus accumben. However, those DNA damage might be caused differently between acute and chronic administration.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
55
3-4
開始ページ
241
終了ページ
245
並び順
241
発行日
2008-08
EDB ID
185829
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系