ID 110880
著者
ナガオ, タミコ Department of Virology, Institute of Health Biosciences, the University of Tokushima Graduate School
ハッチョウ, カズキ Department of Virology, Institute of Health Biosciences, the University of Tokushima Graduate School
ドイ, ナオヤ Department of Virology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧
フジワラ, サチ Department of Virology, Institute of Health Biosciences, the University of Tokushima Graduate School
足立, 昭夫 Department of Virology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
野間口, 雅子 Department of Virology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
HIV-1
Gag
CA
CypA,
TRIM5α
資料タイプ
学術雑誌論文
抄録
We previously generated a prototype monkey-tropic human immunodeficiency virus type 1 (HIV-1) designated NL-DT5R. This viral clone has a small region of simian immunodeficiency virus (SIV) within Gag capsid (CA) protein and also SIV Vif protein, but displays a poor growth phenotype in simian cells. To improve the growth potential of NL-DT5R, we have constructed a series of its gag variant viruses. Out of fourteen viral clones generated, five were infectious for simian HSC-F cells, and two of the infectious variants grew similarly with NL-DT5R. Taking their genome structures into consideration, our data here clearly show that a narrow CA region within the Gag protein, i.e., the domain around cyclophilin A (CypA)-binding loop, is critical for the growth ability of HIV-1 in simian cells.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
56
1-2
開始ページ
21
終了ページ
25
並び順
21
発行日
2009-02
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系