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ID 111018
著者
Kamae, Risa Tokushima University
Nojima, Shoko Osaka City University
Akiyoshi, Kenji Tokushima University
Setsu, Shoki Tokushima University
Honda, Sari Osaka City University
Masuda, Toshiya Osaka City University
キーワード
hydroxyhydroquinone
by-product
coffee
cytotoxicity
lymphocytes
calcium
資料タイプ
学術雑誌論文
抄録
Hydroxyhydroquinone (HHQ) is generated during coffee bean roasting. A cup of coffee contains 0.1–1.7 mg of HHQ. The actions of HHQ on mammalian DNA were examined because HHQ is a metabolite of benzene, which causes leukemia. Currently, information on the cellular actions of HHQ is limited. We examined the effects of sublethal levels of HHQ on the concentration of intracellular Ca2+ in rat thymic lymphocytes by using a flow cytometric technique with fluorescent probes. HHQ at 10 μM or more significantly elevated intracellular Ca2+ levels by increasing the membrane permeability of divalent cations, resulting in hyperpolarization via the activation of Ca2+-dependent K+ channels. HHQ-induced changes in the intracellular Ca2+ concentration and membrane potential may affect the cell functions of lymphocytes. HHQ-reduced coffee may be preferable in order to avoid the possible adverse effects of HHQ.
掲載誌名
Food and Chemical Toxicology
ISSN
02786915
cat書誌ID
AA10627174
AA11526376
出版者
Elsevier
102
開始ページ
39
終了ページ
45
発行日
2017-01-30
権利情報
© 2017 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
生物資源系