直近一年間の累計
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ID 111096
著者
Yamamoto, Akihiro Tottori University
Hashimoto, Kiyoshi Tottori University
Yamasaki, Akira Tottori University
Takata, Miki Tottori University
Morita, Masato Tottori University
Funaki, Yoshihiro Tottori University
Okada, Kensaku Tottori University
Teruya, Yasuhiko Tottori University
Fukushima, Takehito Tottori University
Shimizu, Eiji Tottori University
キーワード
acute exacerbation
idiopathic interstitial pneumonia
idiopathic pulmonary fibrosis
leukocytapheresis
nonspecific interstitial pneumonia
資料タイプ
学術雑誌論文
抄録
Objective : Idiopathic interstitial pneumonias (IIPs) are a group of heterogeneous diffuse parenchymal lung disorders of unknown etiology. An acute exacerbation (AE) is an acute respiratory deterioration that occurs in IIPs. The prognosis of AE of IIPs (AE-IIPs) is extremely severe ; however, no established therapies exist. We aimed to evaluate the efficacy of leukocytapheresis (LCAP) to treat patients with AE-IIPs. Patients and Methods : Six chronic IIPs patients who developed AE were enrolled in this study. We performed LCAP on days 2, 3, 9 and 10 in all six patients. All patients were also treated with high-dose corticosteroids and a continuous administration of low-molecular-weight heparin. We observed 30-day survival after the diagnosis of AE to evaluate the efficacy of LCAP. We also assessed oxygenation, high-resolution computed tomography (HRCT) findings, and certain chemical mediators in the peripheral blood. Results : Five of six patients survived more than 30 days. One patient died of progressive respiratory failure. Oxygenation and HRCT findings tended to improve in all survivors. The serum levels of lactate dehydrogenase, high mobility group box-1, and interleukin-18 were significantly decreased statistically post-LCAP. No severe adverse events occurred. Conclusion :We suggest that LCAP is a safe and effective therapy for treating patients with AE-IIPs.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
64
1-2
開始ページ
110
終了ページ
116
並び順
110
発行日
2017-02
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版