ID | 111096 |
著者 |
Yamamoto, Akihiro
Tottori University
Hashimoto, Kiyoshi
Tottori University
Yamasaki, Akira
Tottori University
Takata, Miki
Tottori University
Morita, Masato
Tottori University
Funaki, Yoshihiro
Tottori University
Okada, Kensaku
Tottori University
Teruya, Yasuhiko
Tottori University
Fukushima, Takehito
Tottori University
Shimizu, Eiji
Tottori University
|
キーワード | acute exacerbation
idiopathic interstitial pneumonia
idiopathic pulmonary fibrosis
leukocytapheresis
nonspecific interstitial pneumonia
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資料タイプ |
学術雑誌論文
|
抄録 | Objective : Idiopathic interstitial pneumonias (IIPs) are a group of heterogeneous diffuse parenchymal lung disorders of unknown etiology. An acute exacerbation (AE) is an acute respiratory deterioration that occurs in IIPs. The prognosis of AE of IIPs (AE-IIPs) is extremely severe ; however, no established therapies exist. We aimed to evaluate the efficacy of leukocytapheresis (LCAP) to treat patients with AE-IIPs. Patients and Methods : Six chronic IIPs patients who developed AE were enrolled in this study. We performed LCAP on days 2, 3, 9 and 10 in all six patients. All patients were also treated with high-dose corticosteroids and a continuous administration of low-molecular-weight heparin. We observed 30-day survival after the diagnosis of AE to evaluate the efficacy of LCAP. We also assessed oxygenation, high-resolution computed tomography (HRCT) findings, and certain chemical mediators in the peripheral blood. Results : Five of six patients survived more than 30 days. One patient died of progressive respiratory failure. Oxygenation and HRCT findings tended to improve in all survivors. The serum levels of lactate dehydrogenase, high mobility group box-1, and interleukin-18 were significantly decreased statistically post-LCAP. No severe adverse events occurred. Conclusion :We suggest that LCAP is a safe and effective therapy for treating patients with AE-IIPs.
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掲載誌名 |
The Journal of Medical Investigation
|
ISSN | 13496867
13431420
|
cat書誌ID | AA11166929
AA12022913
|
出版者 | Faculty of Medicine Tokushima University
|
巻 | 64
|
号 | 1-2
|
開始ページ | 110
|
終了ページ | 116
|
並び順 | 110
|
発行日 | 2017-02
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出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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