アクセス数 : ?
ダウンロード数 : ?
ID 111438
タイトル別表記
ゲラニルゲラニルアセトンはマウスにおいてストレスによるレプチン分泌の減少を防ぐ
GGA and leptin secretion
著者
板井, 美樹 徳島大学大学院医科学教育部(医学専攻)
西川, 達哉 Tokushima University
キーワード
Geranylgeranylacetone
stress
food intake
leptin
ghrelin
資料タイプ
学位論文
抄録
Geranylgeranylacetone (GGA) is a chaperon inducer that protects various types of cell and tissue against stress. We examined whether GGA modulated energy intake and expenditure under stressful conditions. After mice were untreated or treated orally with GGA (0.16 g per kg body weight per day) for 10 days, they were subjected to 2-h restraint stress once or once a day for 5 consecutive days. GGA administration did not affect corticosterone response to the stress. Restraint stress rapidly decreased plasma leptin levels in control mice. GGA significantly increased circulating leptin levels without changing food intake and prevented the stress-induced decline of circulating leptin. However GGA-treated mice significantly reduced food intake during the repeated stress, compared with control mice. GGA prevented the stress-induced decline of leptin mRNA and its protein levels in epidydimal adipose tissues. We also found that GGA decreased ghrelin mRNA expression in gastric mucosa before the stress, whereas GGA-treated mice recovered the ghrelin mRNA expression to the baseline level after the repeated stress. Leptin and ghrelin are now recognized as regulators of anxiety and depressive mood. Our results suggest that GGA may regulate food intake and relief stress-induced mood disturbance through regulating leptin and ghrelin secretions.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
65
1-2
開始ページ
103
終了ページ
109
並び順
103
発行日
2018-02
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Miki Itaiの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3136号
学位記番号
甲医第1370号
学位授与年月日
2018-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系