ID | 111989 |
著者 |
Kishida, Takumi
Tokushima University
Akiyoshi, Kenji
Tokushima University
Erdenedalai, Erdenebat
Tokushima University
Enhetomuru, Anu
Tokushima University
|
キーワード | Dibromoacetonitrile
Water disinfection
Nonprotein thiol
Intracellular Zn2+ level
Lymphocytes
|
資料タイプ |
学術雑誌論文
|
抄録 | The aim of this study was to investigate the effects of dibromoacetonitrile (DBAN), a by-product in water bacterial control, at sublethal concentrations on rat thymocytes, by using a cytometric technique with appropriate fluorescent dyes. By using this method, the possibility that DBAN induces cellular actions related to oxidative stress was assessed. DBAN reduced the content of cellular nonprotein thiols under Zn2+-free conditions. It elevated the intracellular level of Zn2+, being independent from external Zn2+. DBAN increased cell vulnerability to the cytotoxic action of hydrogen peroxide. These actions of DBAN were likely related to oxidative stress. DBAN is formed by the reaction of bromides and chlorinated oxidants during water disinfection. Hydrolysis of 2,2-dibromo-3-nitrilopropionamide, an antimicrobial used in hydraulic fracturing fluids for production of shale gas and oil, produces DBAN. Therefore, the concern regarding the levels of DBAN in industrial water systems is necessary to avoid the environmental risk to humans and wild mammals.
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掲載誌名 |
Toxicology in Vitro
|
ISSN | 08872333
|
cat書誌ID | AA10678594
AA11540107
|
出版者 | Elsevier
|
巻 | 51
|
開始ページ | 145
|
終了ページ | 149
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発行日 | 2018-05-23
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権利情報 | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
著者版
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部局 |
理工学系
生物資源系
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