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ID 112814
タイトル別表記
Shikonin inhibits inflammatory cytokine production
著者
Shindo, Satoru Tokushima University
キーワード
shikonin
IL-6
IL-8
CCL20
NF-κB
periodontal ligament cells
資料タイプ
学術雑誌論文
抄録
Shikonin, which is derived from Lithospermum erythrorhizon, a herb used in traditional medicine, has long been considered to be a useful treatment for various diseases in traditional oriental medicine. Shikonin has recently been reported to have several pharmacological properties, e.g., it has anti-microbial, anti-tumor, and anti-inflammatory effects. The aim of this study was to examine whether shikonin is able to influence the production of interleukin (IL)-6, IL-8, and/or chemokine C-C motif ligand (CCL)20, which contribute to the pathogenesis of periodontal disease, in human periodontal ligament cells (HPDLC). The production levels of IL-6, IL-8, and CCL20 in HPDLC were determined using an ELISA. Western blot analysis was used to detect nuclear factor kappa B (NF-κB) pathway activation in HPDLC. Shikonin prevented IL-1β- or tumor necrosis factor (TNF)-α-mediated IL-6, IL-8, and CCL20 production in HPDLC. Moreover, we found that shikonin suppressed the phosphorylation and degradation of inhibitor of kappa B-alpha (IκB-α) in IL-1β- or TNF-α-stimulated HPDLC. These findings suggest that shikonin could have direct beneficial effects against periodontal disease by reducing IL-6, IL-8, and CCL20 production in periodontal lesions.
掲載誌名
Inflammation
ISSN
03603997
15732576
cat書誌ID
AA00673765
AA12117940
出版者
Springer
39
3
開始ページ
1124
終了ページ
1129
発行日
2016-04-12
備考
This is a post-peer-review, pre-copyedit version of an article published in Inflammation.
The final authenticated version is available online at: https://doi.org/10.1007/s10753-016-0344-0
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
歯学系