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ID 114186
タイトル別表記
PPARγ Loss Leads to Reduced Fertility
著者
Cui, Yongzhi National Institutes of Health
三好, 圭子 National Institutes of Health|The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Claudio, Estefania National Institutes of Health
Siebenlist, Ulrich K. National Institutes of Health
Gonzalez, Frank J. National Institutes of Health
Flaws, Jodi University of Maryland
Wagner, Kay-Uwe University of Nebraska Medical Center
Hennighausen, Lothar National Institutes of Health
資料タイプ
学術雑誌論文
抄録
The peroxisome proliferation-activated receptor gamma (PPARγ) is expressed in many cell types including mammary epithelium, ovary, macrophages, and B- and T-cells. PPARγ has an anti-proliferative effect in pre-adipocytes and mammary epithelial cells, and treatment with its ligands reduced the progression of carcinogen-induced mammary tumors in mice. Because PPARγ-null mice die in utero it has not been possible to study its role in development and tumorigenesis in vivo. To investigate whether PPARγ is required for the establishment and physiology of different cell types, a cell-specific deletion of the gene was carried out in mice using the Cre-loxP recombination system. We deleted the PPARγ gene in mammary epithelium using WAP-Cre transgenic mice and in epithelial cells, B- and T-cells, and ovary cells using MMTV-Cre mice. The presence of PPARγ was not required for functional development of the mammary gland during pregnancy and for the establishment of B- and T-cells. In addition, no increase in mammary tumors was observed. However, loss of the PPARγ gene in oocytes and granulosa cells resulted in impaired fertility. These mice have normal populations of follicles, they ovulate and develop corpora lutea. Although progesterone levels are decreased and implantation rates are reduced, the exact cause of the impaired fertility remains to be determined.
掲載誌名
Journal of Biological Chemistry
ISSN
1083351X
cat書誌ID
AA1202441X
出版者
The American Society for Biochemistry and Molecular Biology
277
20
開始ページ
17830
終了ページ
17835
発行日
2002-03-07
備考
This research was originally published in the Journal of Biological Chemistry. Yongzhi Cui, Keiko Miyoshi, Estefania Claudio, Ulrich K. Siebenlist, Frank J. Gonzalez, Jodi Flaws, Kay-Uwe Wagner and Lothar Hennighausen. Loss of the Peroxisome Proliferation-activated Receptor gamma (PPARγ) Does Not Affect Mammary Development and Propensity for Tumor Formation but Leads to Reduced Fertility. J. Biol. Chem. 2002; 277(20):17830-17835.
権利情報
© The American Society for Biochemistry and Molecular Biology
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系