木下, 貴正 Sapporo City General Hospital|Tokushima University
Imaizumi, Hiroko Sapporo City General Hospital|Tokushima University
Shimizu, Miho Sapporo City General Hospital
Mori, Junya Sapporo City General Hospital
Hatanaka, Akira Sapporo City General Hospital
Aoki, Shuichiro Sapporo City General Hospital
Miyamoto, Hirotomo Sapporo City General Hospital
Iwasaki, Masanori Sapporo City General Hospital
Sano, Hiroki Tokushima University
Sonoda, Shozo Kagoshima University
Sakamoto, Taiji Kagoshima University
Knowledgeof the choroidal structures in eyes with diabetes and diabetic retinopathy (DR) should provide information on the pathogenesis of DR. A prospective study was performed to determine the systemic and ocular factors that affect the choroidal structures in eyes with diabetes. Two-hundred consecutive diabetic subjects consisted of 160 treatment-naïve patients with different stages of DR and 40 patients with proliferative DR with prior panretinal photocoagulation (PRP). All underwent blood and urine tests and enhanced depth imaging optical coherence tomography (EDI-OCT). The cross-sectional EDI-OCT images of the subfoveal choroid were binarized to measure the total choroidal area (TCA), luminal area, and stromal area. Multivariate regression analyses were performed to determine the systemic and ocular factors that were significantly correlated with the choroidal structures. The subfoveal choroidal thickness, TCA, luminal area, and stromal area were larger at more advanced stage of DR, and smaller in eyes with PRP than those without (P < 0.001). The TCA and stromal area were significantly and positively correlated with the degree of albuminuria (P = 0.034, P = 0.025, respectively). The choroidal lumen and stroma may increase as the stages of DR progress and decrease after PRP. Albuminuria may be associated with the choroidal stromal edema.
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