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ID 116640
タイトル別表記
未固定遺体における動脈硬化性冠動脈プラークと冠動脈外膜vasa vasorum及び局所心臓周囲脂肪内炎症との関連
Coronary Plaque and Epicardial Adipose Inflammation
著者
伊藤, 浩敬 徳島大学大学院医科学教育部(医学専攻) 徳島大学 教育研究者総覧
キーワード
Coronary plaque
Epicardial adipose tissue
Fresh cadaver
Inflammatory molecules
Vasa vasorum
資料タイプ
学位論文
抄録
Background: The coronary adventitia has recently attracted attention as a source of inflammation because it harbors nutrient blood vessels, termed the vasa vasorum (VV). This study assessed the link between local inflammation in adjacent epicardial adipose tissue (EAT) and coronary arterial atherosclerosis in fresh cadavers.
Methods and Results: Lesion characteristics in the left anterior descending coronary artery of 10 fresh cadaveric hearts were evaluated using integrated backscatter intravascular ultrasound (IB-IVUS), and the density of the VV and levels of inflammatory molecules from the adjacent EAT were measured for each of the assessed lesions. The lesions were divided into lipid-rich, lipid-moderate, and lipid-poor groups according to percentage lipid volume assessed by IB-IVUS. Higher expression of inflammatory molecules (i.e., vascular endothelial growth factor A [VEGFA] and VEGFB) was observed in adjacent EAT of lipid-rich (n=11) than in lipid-poor (n=11) lesions (7.99±3.37 vs. 0.45±0.85 arbitrary units [AU], respectively, for VEGFA; 0.27±0.15 vs. 0.11±0.07 AU, respectively, for VEGFB; P<0.05). The density of adventitial VV was greater in lipid-rich than lipid-poor lesions (1.50±0.58% vs. 0.88±0.23%; P<0.05).
Conclusions: Lipid-rich coronary plaques are associated with adventitial VV and local inflammation in adjacent EAT in fresh cadavers. This study suggests that local inflammation of EAT is associated with coronary plaque progression via the VV.
掲載誌名
Circulation Journal
ISSN
13474820
出版者
Japanese Circulation Society
84
5
開始ページ
769
終了ページ
775
発行日
2020-04-24
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Hiroyuki Itoの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3564号
学位記番号
甲医第1515号
学位授与年月日
2021-12-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院