アクセス数 : ?
ダウンロード数 : ?
ID 77403
著者
藤井, 笑子 Department of Pediatrics, Institute of Health Biosciences, the University of Tokushima Graduate School
森, 健治 Department of Pediatrics, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
宮崎, 雅仁 Department of Pediatrics, Institute of Health Biosciences, the University of Tokushima Graduate School
橋本, 俊顕 Department of Pediatrics, Tokushima Red Cross Hinomine General Nursing Center
原田, 雅史 Department of Radiologic Technology, School of Health Sciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
香美, 祥二 Department of Pediatrics, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
autism
proton magnetic resonance spectroscopy (1H-MRS)
dorsolateral prefrontal cortex(DLPFC)
anterior cingulated cortex(ACC)
資料タイプ
学術雑誌論文
抄録
Purpose. In this investigation, we studied differences in chemical metabolites in certain brain regions between autistic patients and normal control subjects. Methods. Proton magnetic resonance spectroscopy (1H-MRS) was used to evaluate functional activity in these regions. Specific regions studied were right and left dorsolateral prefrontal cortex(DLPFC) and the anterior cingulated cortex(ACC). Results. In the ACC, the N-acetylaspartate(NAA)/creatine/phosphocreatine(Cr) ratio in autistic patients (n=31) was significantly lower than that in control subjects (n=28). The decrease in the NAA/Cr ratio for the ACC was much greater in the group with worst social ability. NAA/Cr for the left DLPFC and social ability of autistic patients also correlated well. Furthermore, NAA/Cr for the left DLPFC in the group with intelligence quotient (IQ) below 50 was significantly less than in controls. NAA/Cr for the right DLPFC in autistic patients was not decreased compared to controls, and did not correlate with IQ or social ability. Conclusions. These findings suggest neuronal dysfunction in the ACC and left DLPFC in autism, and also a relationship between social disability and metabolic dysfunction in these regions. Dysfunction in the ACC and the left DLPFC may contribute to the pathogenesis of autism.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
57
1-2
開始ページ
35
終了ページ
44
並び順
35
発行日
2010-02
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
フルテキストファイル
言語
eng
部局
医学系