ID 80823
著者
キヨカワ, マチコ Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
松崎, 利也 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
岩佐, 武 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
オガタ, リエ Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
ムラカミ, マサヒロ Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
キノウチ, リヨ Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
ヨシダ, シノブ Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
桑原, 章 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
安井, 敏之 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
苛原, 稔 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
orexin A
luteinizing hormone
neuropeptide Y
gonadotropin-releasing hormone
資料タイプ
学術雑誌論文
抄録
Objectives : Reproductive functions are influenced by various feeding regulators.
Orexin, which is one of orexinergic peptides, suppresses the pulsatile secretion of
luteinizing hormone (LH) in bilaterally ovariectomized (OVX) rats. However, the mechanism
of this effect is still not clear. To investigate whether neuropeptide Y (NPY) is involved
in the orexin A-mediated suppression of pulsatile LH secretion, we evaluated the
effects of NPY antibody on the suppressive effect of orexin A. Methods : Orexin A was administered
intracerebroventricularly (icv) and NPY antibody (NPY-Ab) was injected before
icv administration of orexin A in OVX rats. Pulsatile LH secretion was analyzed by
measuring serum LH concentrations in the next 2 h in blood samples drawn at 6-min intervals
by radioimmunoassay. Results : Administration of orexin A significantly reduced
the mean LH concentration and LH pulse frequency. Co-administration of NPY antibody
with orexin A significantly restored the suppressive effect of orexin A on the mean LH
concentration and LH pulse frequency. Conclusion : NPY mediated the suppressive effect
of intracerebroventricularly injected orexin A on pulsatile LH secretion, suggesting that
hypothalamic orexin suppressed pulsatile gonadotropin-releasing hormone (GnRH) secretion
via NPY in the hypothalamus of female rats.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
58
1-2
開始ページ
11
終了ページ
18
並び順
11
発行日
2011-02
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
フルテキストファイル
言語
eng
部局
医学系
病院