ID 80825
著者
カサイ, ユカ Department of Obstetrics and Gynecology, Tokushima Prefectural Central Hospital
マエガワ, マサヒコ Department of Obstetrics and Gynecology, Tokushima Prefectural Central Hospital
ヤマモト, サトシ Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
カマダ, マサハル Department of Obstetrics and Gynecology,Health Insurance Naruto Hospital
安井, 敏之 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
上村, 浩一 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
コバヤシ, アヤコ Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
カネヤマ, マサヨ Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
タニ, アンナ Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
松井, 寿美佳 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
桑原, 章 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
松崎, 利也 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
古本, 博孝 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
苛原, 稔 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
raloxifene
cytokine
whole blood assay
資料タイプ
学術雑誌論文
抄録
Purpose : The aims of this study were to determine the effects of raloxifene
therapy on production of cytokines and in vitro effects of raloxifene on production of
cytokines by whole blood cultures. Methods :We obtained samples of peripheral blood
from 6 postmenopausal women with osteopenia at baseline and after 3 and 6 months of
raloxifene therapy and 10 postmenopausal women who did not receive raloxifene therapy.
Whole blood from raloxifene-treated women was stimulated with lipopolysaccharide
(LPS) or phytohemeagglutinin (PHA). Whole blood from postmenopausal women who
were not treated with raloxifene was preincubated with raloxifene at concentrations
of 10-10-10-7 M and then stimulated with LPS or PHA. Concentrations of IL-1β, IL-4, IL-6,
IL-12p40, IL-12p70, TNF-α and IFN-γ in the supernatant were measured by respective
ELISAs. Results : In ex vivo cultures, raloxifene therapy inhibited LPS-stimulated production
of IL-1β, IL-6, IL-12p40, IL-12p70 and TNF-α, but not PHA-stimulated production
of IL-4 and IFN-γ. In in vitro cultures, raloxifene at a concentration (10-9 M) inhibited
LPS-stimulated production of IL-1β, IL-6 and IL-12p40 and PHA-stimulated production
of IFN-γ. Conclusions : Raloxifene therapy decreases the production of IL-1β,
IL-6, IL-12 and TNF-α but not that of IL-4 and IFN-γ, suggesting that modulation of
cytokines could play a role in the mechanisms of the osteoprotective effect of raloxifene.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
58
1-2
開始ページ
110
終了ページ
117
並び順
110
発行日
2011-02
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
227446
フルテキストファイル
言語
eng
部局
医学系
病院