ID 83813
著者
梶, 龍兒 Division of Advanced Clinical Neuroscience, University Hospital, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
Basal ganglia
Parkinson's disease
dystonia
sensory-motor integration
muscle afferent block
資料タイプ
学術雑誌論文
抄録
Basal ganglia lie between the cerebral cortex and the thalamus, and have dense fiber connections between them. These connections form 4-5 distinct loops or circuits to allow parallel processing of information. Among them, the most intensively studied is the motor loop, which comprises 2 distinct direct and indirect pathways. The direct pathway disinhibits the powerful inhibition of the internal segment of the globus pallidus/substantia nigra pars reticulata upon thalamic ventrolateral nuclei with a net result of facilitatory influence upon the motor cortex. By contrast, the indirect pathway exerts an inhibitory effect. Overall this dual system provides a center (excitatory)-surround (inhibitory) mechanism to focus its effect on selected cortical neurons. Although putative transmitters, inhibitory or excitatory nature of these projections and their receptors are mostly known, the functional role of the loop in motor control is not precisely understood. Several lines of evidence have recently been presented to support the view that this center-surround mechanism is used to focus the output to a specific group of muscles required for performing a specific task. This operation is made possible through opening the sensory channel for the expected sensory feed-back afferents during movement. Thus one of the important functions of basal ganglia seems to be the gating of sensory input for motor control.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
48
3-4
開始ページ
142
終了ページ
146
並び順
142
発行日
2001
備考
フルテキストファイル
言語
eng
部局
医学系