ID 113270
タイトル別表記
子宮内膜症モデルマウスにおいてアクチビンの腹腔内投与は子宮内膜症様病変の増殖を促進する
Activin A promotes endometriotic lesions
著者
笠井, 可菜 徳島大学大学院医科学教育部(医学専攻)
Kadota, Yuri Tokushima University
Erdenebayar, Otgontsetseg Tokushima University
吉田, 加奈子 Tokushima University
キーワード
Endometriosis
Activin A
Mouse model
Inflammatory cytokine
資料タイプ
学位論文
抄録
PURPOSE : This study aimed to investigate the effect of intraperitoneal administration of activin on the occurrence of endometriosis using a mouse model of endometriosis. METHODS : A mouse model of endometriosis was prepared by intraperitoneally administering endometrial tissue and blood collected from donor mice to C57BL/6J 7-8- week-old recipient mice. A total of 400 μg of activin A was intraperitoneally administered to model mice in the activin group for 5 days. Intraperitoneal endometriotic lesions were confirmed macroscopically and IL-6 and TNF-α levels in washed ascites were measured by ELISA. RESULTS : Endometriotic lesions were observed in all mice. In the activin group, the maximum diameter of endometriotic lesions was significantly larger than that in control group (4.7±1.3 vs 2.9±0.9 mm, p<0.01). The total area of the lesion was also significantly higher in the activin group than in the control group (21.1±9.9 vs 8.8±5.4 mm2, p<0.01). Furthermore, IL-6 and TNF-α levels in ascites were significantly higher in the activin group than in the control group (IL-6 : 85.8±15.3 vs 75.1±19.3 pg/ml, p<0.05 ; TNF-α : 629.8±15.4 vs 605.9±11.4 pg/ml, p<0.05). CONCLUSION : Activin promotes occurrence of endometriosis. Inflammatory cytokines are also elevated by activin administration,suggesting that they may contribute to progression of endometriosis
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA12022913
AA11166929
出版者
Tokushima University Faculty of Medicine
66
1-2
開始ページ
123
終了ページ
127
並び順
123
発行日
2019-02
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Kana Kasaiの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3253号
学位記番号
甲医第1402号
学位授与年月日
2019-02-06
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院