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ダウンロード数 : ?
ID 113348
著者
Komiya, Chiaki Tokushima University
Tsukimoto, Jun Tokushima University
Ueda, Masahiro Tokushima University
Morisaki, Takuya Tokushima University
資料タイプ
学術雑誌論文
抄録
A traceless thioester-producing protocol featuring carboxypeptidase Y-mediated hydrazinolysis of cysteinyl prolyl leucine-tagged peptides has been developed. The hydrazinolysis followed by thioesterification affords cysteinyl prolyl thioesters. Self-editing of the tag and subsequent trans-thioesterification yields peptide thioesters. The developed protocol was successfully applied to conversion of recombinant proteins to thioesters.
掲載誌名
Chemical Communications
ISSN
13597345
1364548X
cat書誌ID
AA11071130
AA12455105
出版者
The Royal Society of Chemistry
55
49
開始ページ
7029
終了ページ
7032
発行日
2019-05-23
権利情報
©The Royal Society of Chemistry 2019
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
薬学系