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ID 106159
タイトル別表記
マウスにおいて短期間の食餌性リン制限は回腸fibroblast growth factor 15遺伝子発現量を増加させる
著者
中橋, 乙起 徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
山本, 浩範 University of Tokushima|Jin-ai University|University of Fukui KAKEN研究者をさがす
Tanaka, Sarasa University of Tokushima
Kozai, Mina University of Tokushima
Takei, Yuichiro University of Tokushima
Iwano, Masayuki University of Fukui
キーワード
fibroblast growth factor 15
gene regulation analysis
inorganic phosphate
1,25-dihydroxyvitamin D
mice
資料タイプ
学位論文
抄録
Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy. It has been reported that dietary Pi regulates circulating FGF23. In this study, the short-term effects of dietary Pi restriction on the expression of FGF19 subfamily members in mice were analyzed. An initial analysis confirmed plasma FGF23 levels positively correlated with the amount of dietary Pi. On the other hand, ileal Fgf15 gene expression, but not hepatic Fgf21 gene expression, was up-regulated by dietary Pi restriction. In addition, we observed the increase of plasma 1,25-dihydroxyvitamin D [1,25(OH)2D] levels by dietary Pi restriction, and the up-regulation of ileal Fgf15 mRNA expression by 1,25(OH)2D3 and vitamin D receptor (VDR). Importantly, dietary Pi restriction-induced Fgf15 gene expression was prevented in VDR-knockout mice. Furthermore, diurnal variations of plasma triglyceride concentrations and hepatic mRNA expression of the bile acid synthesis enzyme Cyp7a1 as one of Fgf15 negative target genes was influenced by dietary Pi restriction. These results suggest that dietary Pi restriction up-regulates ileal Fgf15 gene expression through 1,25(OH)2D3 and VDR, and may affect hepatic bile acid homeostasis.
掲載誌名
Journal of Clinical Biochemistry and Nutrition
ISSN
18805086
09120009
cat書誌ID
AA10710201
出版者
SOCIETY FOR FREE RADICAL RESEARCH JAPAN
54
2
開始ページ
102
終了ページ
108
発行日
2014-03-01
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201405161005.pdf
論文本文 : k2678_fulltext.pdf
本論文は, 著者Otoki Nakahashiの学位論文として提出され, 学位審査・授与の対象となっている。
著者の申請により要約(2014-07-24公開)に替えて論文全文を公開(2020-04-10)
権利情報
© 2014 Society for Free Radical Research Japan
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2678号
学位記番号
甲栄第212号
学位授与年月日
2014-03-24
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系