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ID 113584
タイトル別表記
ROLE OF RUNX3 IN HEAD AND NECK CANCER
著者
高田, 隆 Hiroshima University
キーワード
RUNX3
ONCOGENE
HEAD AND NECK CANCER
資料タイプ
学術雑誌論文
抄録
Cumulative evidences show that Runt-related transcription factor 3 (RUNX3) has a tumor suppressive role in various cancers. In particular, RUNX3 appears to be an important component of the transforming growth factor-beta (TGF-ß)-induced tumor suppression pathway. Contrary to reports on this tumor suppressive role of RUNX3, RUNX3 can also function as an oncogene when overexpressed. Recently, we found that RUNX3 overexpression was frequently observed and was well correlated with malignant behaviors in head and neck cancer, which is one of the most common types of human cancer. Moreover, it has been revealed that RUNX3 overexpression promoted cell growth and inhibited apoptosis in head and neck cancer cells. This review introduces the oncogenic role of RUNX3 in certain types of cancer including head and neck cancer.
掲載誌名
Journal of Cellular Biochemistry
ISSN
07302312
10974644
cat書誌ID
AA1052210X
出版者
Wiley-Liss
112
2
開始ページ
387
終了ページ
393
発行日
2010-12-06
権利情報
This is the peer reviewed version of the following article: Kudo, Y. , Tsunematsu, T. and Takata, T. (2011), Oncogenic role of RUNX3 in head and neck cancer. J. Cell. Biochem., 112: 387-393, which has been published in final form at https://doi.org/10.1002/jcb.22967. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
歯学系
医学系