ID | 110564 |
タイトルヨミ | ナゼ アレルギー シッカン ワ ゾウカ シテ イルノカ : メンエキガク ノ タチバ ヨリ
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タイトル別表記 | What increases allergic diseases in recent years? : from the view of immunology
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著者 |
久枝, 一
徳島大学大学院医学研究科病態予防医学講座生体防御医学分野
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キーワード | type I allergy
IgE
Th2
mast cell
infection
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資料タイプ |
学術雑誌論文
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抄録 | Type I allergic diseases, such as rhinitis, pollinosis and bronchial asthma, are mediated by Th2-type helper T cell induction, specific IgE antibody production and mast cell activation. Increases of these allergic diseases in recent years might be caused by skewed differentiation of T cells toward Th2 cells by some environmental factors including diesel exhaust particles and decreases of virus and bacteria infection in childhood. The decrease of parasite infection is also thought to affect the susceptibility against allergic diseases by eliciting polyclonal IgE production that suppresses mast cell activation. Important clues for prevention and therapy of the allergic diseases would be derived from further investigations of the relationship between the diseases and these environmental factors.
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掲載誌名 |
四国医学雑誌
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ISSN | 00373699
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cat書誌ID | AN00102041
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出版者 | 徳島医学会
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巻 | 58
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号 | 6
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開始ページ | 265
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終了ページ | 266
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並び順 | 265
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発行日 | 2002-12-25
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フルテキストファイル | |
言語 |
jpn
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著者版フラグ |
出版社版
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部局 |
医学系
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