直近一年間の累計
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ID 110729
著者
Sun, Xue-Zhi Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences
タカハシ, センタロウ Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences
クボタ, ヨシヒサ Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences
Zhang, Rui Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine
Cui, Chun Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine
ノジマ, クミエ Research Laboratory of Space Radiation, National Institute of Radiological Sciences
福井, 義浩 Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
cerebral hemisphere
heavy-ion beam
irradiation
資料タイプ
学術雑誌論文
抄録
Heavy-ion beams have the feature to administer a large radiation dose in the vicinity of the endpoint in the beam range, its irradiation system and biophysical characteristics are different from ordinary irradiation instruments like X-rays or gamma-rays. In order to get clarify characteristic effects of heavy-ion beams on the brain, we have developed an experimental system for irradiating a restricted region of the rat brain using heavy-ion beams. The left cerebral hemispheres of the adult rat brain were irradiated at dose of 50Gy charged carbon particles (290MeV/nucleon 5mmspread-out Bragg peak). After irradiation, the characteristics of the heavy-ion beams and the animal model were studied. Histological examination and measurement showed that extensive necrosis was observed between 2.5mmand7.5mmdepth from the surface of the rat head, suggesting a relatively high dose and uniform dose was delivered among designed depths and the spread-out bragg peak used here successfully and satisfactorily retained its high-dose localization in the defined region. We believe that our experimental model for irradiating a restricted region of the rat brain using heavy-ion beams is a good model for analyzing regional radiation susceptibility of the brain.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
51
1-2
開始ページ
103
終了ページ
107
並び順
103
発行日
2004-02
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系