パラコート含有除草剤中毒に対する医療用樹脂の使用に関する基礎的検討

The removal characteristics of paraquat and diquat by medical cation exchange resins (kayexalate and kalimate) for primary treatment of acute poisoning due to the accidental, suicidal or homicidal ingestion of herbicide were investigated in vitro.
The removed amounts of paraquat and diquat by kayexalate was larger than those by kalimate. And it was recognized that kayexalate is selective remover for paraquat and kalimate for diquat.
The inhibitory effect of sodium chloride addition on the paraquat and diquat removal by medical cation exchange resin was recognized. The degree of interference was proportional to the amount of sodium chloride added in the range of sodium chloride concentration up to 1.5%. The inhibitory effect of magnesium sulfide on the paraquat and diquat removal was also recognized. The degree of interference by saline addition onto kalimate was smaller compared with the case of kayexalate.
It is assumed that the difference of removal amount between paraquat and diquat by resins is due to the different strength of the polarity of paraquat and diquat. And it is assumed that the difference of removal effects between kayexalate and kalimate is due to the cation exchange capacity of resins.
The medical cation exchange resin is evaluated as the effective oral adsorbent, but it has to pay attention to the inhibitory effect of saline addition for the removal characteristics for paraquat and diquat by medical cation exchange resins from the standpoint of in vitro study.