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ID 113367
タイトル別表記
成長期における食餌性リンによるα-klotho発現制御
著者
多々納(福田), 詩織 徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
山本, 浩範 University of Tokushima|Jin-ai University|University of Fukui KAKEN研究者をさがす
Nakahashi, Otoki University of Tokushima|Tokushima Bunri University
Yoshikawa, Ryouhei University of Tokushima
Hayashi, Mayu University of Tokushima
Kishimoto, Maki University of Tokushima
伊美, 友紀子 Konan Women’s University
キーワード
Dietary phosphate
Growth periods
α-Klotho
FGF23
Vitamin D metabolism
Kidney
資料タイプ
学位論文
抄録
Inorganic phosphate (Pi) is an essential nutrient for maintaining various biological functions, particularly during growth periods. Excess intake of dietary Pi increases the secretion of fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) to maintain plasma Pi levels. FGF23 is a potent phosphaturic factor that binds to the α-klotho/FGFR complex in the kidney to promote excretion of Pi into the urine. In addition, excess intake of dietary Pi decreases renal α-klotho expression. Down-regulation or lack of α-klotho induces a premature aging-like phenotype, resulting from hyperphosphatemia, and leading to conditions such as ectopic calcification and osteoporosis. However, it remains unclear what effects dietary Pi has on α-klotho expression at different life stages, especially during growth periods. To investigate this, we used C57BL/6J mice in two life stages during growing period. Weaned (3 weeks old) and periadolescent (7 weeks old) were randomly divided into seven experimental groups and fed with 0.02, 0.3, 0.6, 0.9, 1.2, 1.5, or 1.8% Pi diets for 7 days. As a result, elevated plasma Pi and FGF23 levels and decreased renal α-klotho expression were observed in weaned mice fed with a high Pi diet. In addition, a high Pi diet clearly induced renal calcification in the weaned mice. However, in the periadolescent group, renal calcification was not observed, even in the 1.8% Pi diet group. The present study indicates that a high Pi diet in weaned mice has much greater adverse effects on renal α-klotho expression and pathogenesis of renal calcification compared with periadolescent mice.
掲載誌名
Calcified Tissue International
ISSN
0171967X
14320827
cat書誌ID
AA00141085
出版者
Springer Nature
104
6
開始ページ
667
終了ページ
678
発行日
2019-01-23
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Shiori Fukuda-Tatanoの学位論文として提出され,学位審査・授与の対象となっている。
This is a post-peer-review, pre-copyedit version of an article published in Calcified Tissue International.
The final authenticated version is available online at: https://doi.org/10.1007/s00223-019-00525-0
権利情報
© 2019, Springer Nature
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3278号
学位記番号
甲栄第267号
学位授与年月日
2019-03-22
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系