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ID 115522
タイトル別表記
Fever and Total Mechanical Ventilation Time in Critically Ill Patients
著者
Park, Dong Won Hanyang University
Egi, Moritoki Kobe university
Chang, Youjin Chungbuk National University
Suh, Gee Young Sungkyunkwan University
Lim, Chae-Man University of Ulsan
Kim, Jae Yeol Chung-Ang University
Tada, Keiichi Hiroshima City Hospital
Matsuo, Koichi New Tokyo Hospital
Takeda, Shinhiro Nippon Medical School
Tsuruta, Ryosuke Yamaguchi University
Yokoyama, Takeshi Teine Keijinkai Hospital
Kim, Seon-Ok University of Ulsan
Koh, Younsuck University of Ulsan
キーワード
Body Temperature
Intensive Care Units
Mechanical Ventilation
Fever
資料タイプ
学術雑誌論文
抄録
This research aims to investigate the impact of fever on total mechanical ventilation time (TVT) in critically ill patients. Subgroup analysis was conducted using a previous prospective, multicenter observational study. We included mechanically ventilated patients for more than 24 hours from 10 Korean and 15 Japanese intensive care units (ICU), and recorded maximal body temperature under the support of mechanical ventilation (MAXMV). To assess the independent association of MAXMV with TVT, we used propensity-matched analysis in a total of 769 survived patients with medical or surgical admission, separately. Together with multiple linear regression analysis to evaluate the association between the severity of fever and TVT, the effect of MAXMV on ventilator-free days was also observed by quantile regression analysis in all subjects including non-survivors. After propensity score matching, a MAXMV ≥ 37.5°C was significantly associated with longer mean TVT by 5.4 days in medical admission, and by 1.2 days in surgical admission, compared to those with MAXMV of 36.5°C to 37.4°C. In multivariate linear regression analysis, patients with three categories of fever (MAXMV of 37.5°C to 38.4°C, 38.5°C to 39.4°C, and ≥ 39.5°C) sustained a significantly longer duration of TVT than those with normal range of MAXMV in both categories of ICU admission. A significant association between MAXMV and mechanical ventilator-free days was also observed in all enrolled subjects. Fever may be a detrimental factor to prolong TVT in mechanically ventilated patients. These findings suggest that fever in mechanically ventilated patients might be associated with worse mechanical ventilation outcome.
掲載誌名
Journal of Korean Medical Science
ISSN
10118934
15986357
cat書誌ID
AA10730934
出版者
The Korean Academy of Medical Sciences
31
12
開始ページ
2033
終了ページ
2041
発行日
2016-10-10
権利情報
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系