| ID | 118986 |
| タイトル別表記 | Gene–lifestyle interactions on obesity
|
| 著者 |
Nakamura, Sho
Kanagawa University of Human Services|Kanagawa Cancer Center Research Institute
Fang, Xuemin
Kanagawa University of Human Services
Saito, Yoshinobu
Kanagawa Cancer Center Research Institute|Kanagawa University of Human Services|Nippon Sport Science University
Narimatsu, Hiroto
Kanagawa University of Human Services|Kanagawa Cancer Center Research Institute|Kanagawa Cancer Center
Ota, Azusa
Kyushu University
Ikezaki, Hiroaki
Kyushu University
Shimanoe, Chisato
Saga University
Tanaka, Keitaro
Saga University
Kubo, Yoko
Nagoya University
Tsukamoto, Mineko
Nagoya University
Tamura, Takashi
Nagoya University
Hishida, Asahi
Nagoya University
Oze, Isao
Aichi Cancer Center Research Institute
Koyanagi, Yuriko N.
Aichi Cancer Center Research Institute
Nakamura, Yohko
Chiba Cancer Center Research Institute
Kusakabe, Miho
Chiba Cancer Center Research Institute
Takezaki, Toshiro
Kagoshima University
Nishimoto, Daisaku
Kagoshima University
Suzuki, Sadao
Nagoya City University
Otani, Takahiro
Nagoya City University
Kuriyama, Nagato
Kyoto Prefectural University of Medicine|Shizuoka Graduate University of Public Health
Matsui, Daisuke
Kyoto Prefectural University of Medicine
Kuriki, Kiyonori
University of Shizuoka
Kadota, Aya
Shiga University of Medical Science
Nakamura, Yasuyuki
Shiga University of Medical Science|Takeda Hospital Medical Examination Center
Nakatochi, Masahiro
Nagoya University
Momozawa, Yukihide
RIKEN
Kubo, Michiaki
RIKEN
Takeuchi, Kenji
Nagoya University|Tohoku University
Wakai, Kenji
Nagoya University
|
| 資料タイプ |
学術雑誌論文
|
| 抄録 | Background
The relationship between lifestyle and obesity is a major focus of research. Personalized nutrition, which utilizes evidence from nutrigenomics, such as gene–environment interactions, has been attracting attention in recent years. However, evidence for gene–environment interactions that can inform treatment strategies is lacking, despite some reported interactions involving dietary intake or physical activity. Utilizing gene–lifestyle interactions in practice could aid in optimizing interventions according to genetic risk. Methods This study aimed to elucidate the effects of gene–lifestyle interactions on body mass index (BMI). Cross-sectional data from the Japan Multi-Institutional Collaborative Cohort Study were used. Interactions between a multi-locus genetic risk score (GRS), calculated from 76 ancestry-specific single nucleotide polymorphisms, and nutritional intake or physical activity were assessed using a linear mixed-effect model. Results The mean (standard deviation) BMI and GRS for all participants (n = 12,918) were 22.9 (3.0) kg/m2 and -0.07 (0.16), respectively. The correlation between GRS and BMI was r(12,916) = 0.13 (95% confidence interval [CI] 0.11–0.15, P < 0.001). An interaction between GRS and saturated fatty acid intake was observed (β = -0.11, 95% CI -0.21 to -0.02). An interaction between GRS and n-3 polyunsaturated fatty acids was also observed in the females with normal-weight subgroup (β = -0.12, 95% CI -0.22 to -0.03). Conclusion Our results provide evidence of an interaction effect between GRS and nutritional intake and physical activity. This gene–lifestyle interaction provides a basis for developing prevention or treatment interventions for obesity according to individual genetic predisposition. |
| 掲載誌名 |
PLOS ONE
|
| ISSN | 19326203
|
| 出版者 | PLOS
|
| 巻 | 18
|
| 号 | 2
|
| 開始ページ | e0279169
|
| 発行日 | 2023-02-08
|
| 権利情報 | This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
|
| EDB ID | |
| 出版社版DOI | |
| 出版社版URL | |
| フルテキストファイル | |
| 言語 |
eng
|
| 著者版フラグ |
出版社版
|
| 部局 |
医学系
|
