生活習慣病と蛋白尿（CKD）陽性頻度に関する臨床的検討 : とくに, 血中脂肪酸分画との関連について

In recent years, it was markedly noticed that metabolic syndrome were related with chronic kidney disease（CKD）, and then out of 349 medical mass examination 159 participants（age : 66.9 ±9.4 y. o）were examined clinical parameters, such as BMI, Waist obesity, TG, HDL-C, LDL-C, FPG, F-IRI, HOMA-IR, Adiponectin, Leptin, as the serum fraction of polyunsaturated fatty acids（DHLA, AA, EPA, DHA）, in admission spotty proteinuria, serum creatinine and GFR were estimated respectively. Positive proteinuria group were allowed the high frequency of HT, MetS and elevated HOMA-IR, especially male were lowed AA/EPA, GFR was significantly related with age and SP, what’s more obesity indicated HT, low HDL-C, high TG, elevated HONA-IR, low adiponecin high Leptin, high EPA high DHA. Moreover HbA1c ≧5.4 groups observed high incidence of HT, MetS and proteinuria, besides HT significantly observed each of the obesity, MetS, elevated HOMA-IR, low Adipo, high Leptin, elevated DHLA and declined GFR. Systolic blood pressure were suggested the positive relation to age, obesity, HOMA-IR, Leptin, DHLA, EPA, but A/L, GFR negatively. Clinical characteristics of MetS were high HOMA-IR, low Adipo, high Leptin, elevated DHLA, high frequency of proteinuria and lowered GFR in male. From above results, MetS was strongly related to CKD, it was thought that spotty proteinuria were suggested the detection of endothelial cell injury on early stage of glomerulosclerosis to be concerned in the metabolism of PUFAs.