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ID 114359
タイトル別表記
Allele Loss in MEN 1-associated Pituitary Tumor
著者
Iwahana, Hiroyuki The University of Tokushima
Kubo, Katsuyuki The University of Tokushima
齋藤, 史郎 The University of Tokushima
キーワード
Allele loss
Chromosome 11
Pituitary tumor
Multiple endocrine neoplasia type 1
資料タイプ
学術雑誌論文
抄録
We have examined the allele loss of chromosome 11 in a pituitary tumor from a patient with familial multiple endocrine neoplasia type 1 (MEN 1). The extensive loss of chromosome 11, including loci of D11S149, HRAS1 and F2, was detected by the loss of heterozygosity. All of the lost alleles of these loci were transmitted from the unaffected father and not from an affected mother. This is the first evidence of allele loss of chromosome 11 in a pituitary tumor of MEN 1 and supports the idea that similar allelic deletion of MEN1 locus on chromosome 11 is the common genetic basis for tumorigenesis in the pituitary, endocrine pancreas, and parathyroid gland in MEN 1.
掲載誌名
Japanese Journal of Cancer Research
cat書誌ID
AA00690844
出版者
Japanese Cancer Association|John Wiley & Sons
82
8
開始ページ
886
終了ページ
889
発行日
1991-08
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系
先端酵素学研究所