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ID 113598
タイトル別表記
Periostin as an Invasion-Promoting Factor in HNSCC
Periostin promotes invasion and anchorage-independent growth in head and neck cancer
著者
Ogawa, Ikuko Hiroshima University
Kitajima, Shojiro Hiroshima University
Kitagawa, Masae Hiroshima University
Kawai, Hidehiko Hiroshima University
Gaffney, Patrick M. University of Minnesota
宮内, 睦美 Hiroshima University
高田, 隆 Hiroshima University
キーワード
Periostin
invasion
metastasis
head and neck cancer
anchorage-independent growth
資料タイプ
学術雑誌論文
抄録
Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of human cancer. Typically HNSCC cells show persistent invasion that frequently leads to local recurrence and distant lymphatic metastasis. However, molecular mechanisms associated with invasion and metastasis of HNSCC remain poorly understood. Here we identified Periostin as an invasion promoting factor in HNSCC by comparing the gene expression profiles between parent HNSCC cells and a highly invasive clone. Indeed, Periostin overexpression promoted the invasion and anchorage independent growth both in vitro and in vivo in HNSCC cells. Moreover, Periostin overexpressing cells spontaneously metastasized to cervical lymph nodes and to the lung through their aggressive invasiveness in an orthotopic mouse model of HNSCC. Interestingly, Periostin was highly expressed in HNSCCs in comparison with normal tissues, and the level of Periostin expression was well correlated with the invasiveness of HNSCC cases. In summary, these findings suggest that Periostin plays an important role for invasion and anchorage independent growth in the metastatic process of HNSCC.
掲載誌名
Cancer Research
ISSN
00085472
15387445
cat書誌ID
AA00598557
AA12004911
出版者
The American Association for Cancer Research
66
14
開始ページ
6928
終了ページ
6935
発行日
2006-07-18
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
歯学系