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ID 113581
タイトル別表記
MMP-13 Promotes Tumor Angiogenesis
著者
工藤, 保誠 Hiroshima University|The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Iizuka, Shinji Hiroshima University
Yoshida, Maki Hiroshima University
Kondo, Tomoyuki The University of Tokushima
Subarnbhesaj, Ajiravudh Hiroshima University
Deraz, Elsayed M. Hiroshima University
Siriwardena, Samadarani B. S. M. Hiroshima University
Tahara, Hidetoshi Hiroshima University
Ogawa, Ikuko Hiroshima University
高田, 隆 Hiroshima University
資料タイプ
学術雑誌論文
抄録
Background: Angiogenesis is an important step in the metastatic cascade of tumors.
Results: MMP-13 itself as well as VEGF-A secretion from fibroblasts promotes angiogenesis. Indeed, MMP-13 is well correlated with blood vessel density in human cancer tissues.
Conclusion: MMP-13 can be a marker for prediction of malignant behaviors and a therapeutic target in cancer.
Significance: This work provides new insights regarding the role of MMP-13 in tumor angiogenesis.
掲載誌名
Journal of Biological Chemistry
ISSN
1083351X
cat書誌ID
AA1202441X
出版者
The American Society for Biochemistry and Molecular Biology
287
46
開始ページ
38716
終了ページ
38728
発行日
2012-09-19
備考
This research was originally published in the Journal of Biological Chemistry. Yasusei Kudo, Shinji Iizuka, Maki Yoshida, Takaaki Tsunematsu, Tomoyuki Kondo, Ajiravudh Subarnbhesaj,
Elsayed M. Deraz, Samadarani B. S. M. Siriwardena, Hidetoshi Tahara, Naozumi Ishimaru, Ikuko Ogawa, and Takashi Takata. Matrix Metalloproteinase-13 (MMP-13) Directly and Indirectly
Promotes Tumor Angiogenesis. J. Biol. Chem. 2012; Vol:287(46) pp.38716-38728.
権利情報
© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系
医学系