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ID 111269
著者
Watanabe, Masanari Tottori University
Kurai, Jun Tottori University
Minato, Sayaka Tottori Prefectural Institute of Health and Environment
Noma, Hisashi Institute of Statistical Mathematics
Sano, Hiroyuki Kindai University
Saito, Rumiko Tohoku University
Aiba, Setsuya Tohoku University
Oshimura, Mitsuo Tottori University
Hatakeyama, Keisuke Tottori Prefectural Institute of Health and Environment
Yamasaki, Akira Tottori University
Shimizu, Eiji Tottori University
キーワード
particulate matter
pro-inflammatory cytokine
interleukin-8
資料タイプ
学術雑誌論文
抄録
Background : Airborne particulate matter (PM) may stimulate production of pro-inflammatory cytokines, and thus exposure to PM affects pulmonary diseases. However, the effects of PM on pulmonary diseases have differed among studies. Methods : PM was collected from February 2 to 28 (winter) and June 1 to 17 (summer) in 2013 in Yurihama, Japan, using filters to separate particles with different aerodynamic diameters (1.1 to< 2.2 μm, 2.2 to< 3.3 μm, 3.3 to< 7.0 μm, and 7.0 to< 10 μm). Interleukin (IL)-8 transcriptional activity in THP-G8 cells was examined in response to winter and summer PM with different diameters. Results : IL-8 transcriptional activity induced by winter PM was significantly higher than that with summer PM for each diameter. For winter PM, IL-8 activity increased with an increased diameter, whereas this activity did not differ between a solvent control and each summer PM diameter. This indicates that summer PM does not stimulate production of IL-8 in THP-G8 cells. Conclusion : The effects of PM on production of pro-inflammatory cytokines differ with the season and PM diameter. This suggests that the compositions of PM differ on season, and the evaluation of compositions of PM is important in understanding the association of health with short-term exposure to PM.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
62
3-4
開始ページ
145
終了ページ
148
並び順
145
発行日
2015-08
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版