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ID 114339
タイトル別表記
CSC with and without steroids
著者
Araki, Takashi Hyogo College of Medicine|JCREST (Japan Clinical Retina Study) group
Ishikawa, Hiroto Hyogo College of Medicine|JCREST (Japan Clinical Retina Study) group
Iwahashi, Chiharu JCREST (Japan Clinical Retina Study) group|Sumitomo Hospital
仁木, 昌徳 JCREST (Japan Clinical Retina Study) group|Tokushima University 徳島大学 教育研究者総覧
三田村, 佳典 JCREST (Japan Clinical Retina Study) group|Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Sugimoto, Masahiko JCREST (Japan Clinical Retina Study) group|Mie University
Kondo, Mineo JCREST (Japan Clinical Retina Study) group|Mie University
木下, 貴正 JCREST (Japan Clinical Retina Study) group|Sapporo City General Hospital
Nishi, Tomo JCREST (Japan Clinical Retina Study) group|Nara Medical University
Ueda, Tetsuo JCREST (Japan Clinical Retina Study) group|Nara Medical University
Kato, Aki JCREST (Japan Clinical Retina Study) group|Nagoya City University
Yasukawa, Tsutomu JCREST (Japan Clinical Retina Study) group|Nagoya City University
Takamura, Yoshihiro JCREST (Japan Clinical Retina Study) group|Fukui University
Gomi, Fumi Hyogo College of Medicine|JCREST (Japan Clinical Retina Study) group
資料タイプ
学術雑誌論文
抄録
We investigated the rates of the use of steroids in Japanese central serous chorioretinopathy (CSC) cases and differences in the characteristics of CSC with and without steroids. A total of 538 eyes of 477 patients diagnosed with CSC, with 3 months or more of follow-up between April 2013 and June 2017 at 8 institutions. Patients with CSC with more than 3 months of follow-up were identified by OCT and fluorescein angiography at 8 institutions. Data collected included patient demographics, history of corticosteroid medication and smoking, spherical errors, findings of angiography, subfoveal choroidal thickness, and changes through the follow-up period. Differences in these findings were analyzed in cases with and without corticosteroid treatment. Among the 477 patients (344 men,133 women), 74 (15.5%) (39 men, 35 women) underwent current or prior steroid treatment. Cases with steroids were higher age (p = 0.0403) and showed no male prevalence, more bilateral involvement (p < 0.0001), and the affected eyes had multiple pigment epithelial detachment (p <0.0001), more fluorescein leakage sites (p < 0.0001), greater choroidal thickness (p = 0.0287) and a higher recurrence rate (p = 0.0412). Steroids can cause severer CSC through an effect on choroidal vessels and an impairment of retinal pigment epithelium.
掲載誌名
PLOS ONE
ISSN
19326203
出版者
PLOS
14
2
開始ページ
e0213110
発行日
2019-02-28
権利情報
© 2019 Araki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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言語
eng
著者版フラグ
出版社版
部局
医学系
病院