ID 111875
著者
Sawada, Jun-ichi University of Shizuoka
Osawa, Ayumi The University of Tokushima|Hokkaido University
Takeuchi, Tomoki Kyoto University
Kaneda, Masato Kyoto University
Oishi, Shinya Kyoto University
Fujii, Nobutaka Kyoto University
Asai, Akira University of Shizuoka
Tanino, Keiji Hokkaido University
キーワード
kinesin spindle protein
KSP
probe
triazapentalene
資料タイプ
学術雑誌論文
抄録
1,3a,6a-Triazapentalene is a compact fluorescent chromophore. In this study, triazapentalene was used to modify a series of biphenyl-type inhibitors of kinesin spindle protein (KSP) to develop fluorescent probes for the intracellular visualization of this protein. Microscopic studies demonstrated that these novel triazapentalene-labeled compounds exhibited inhibitory activity towards KSP in cultured cells and provided important information concerning the intracellular distribution.
掲載誌名
Bioorganic & Medicinal Chemistry Letters
ISSN
0960894X
cat書誌ID
AA11522706
出版者
Elsevier
26
23
開始ページ
5765
終了ページ
5769
発行日
2016-10-15
権利情報
© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
薬学系