ID 111910
著者
Ebisuno, Koji The University of Tokushima
Denda, Masaya The University of Tokushima
Ogura, Keiji The University of Tokushima
キーワード
caged peptide
nonhydrolyzable
phosphoamino acid
phosphopeptide
UV-responsive
資料タイプ
学術雑誌論文
抄録
The design and synthesis of caged non-hydrolyzable phospho-serine, -threonine, and -tyrosine derivatives that generate parent non-hydrolyzable phosphoamino acids, containing a difluoromethylene unit instead of the oxygen of a phosphoester, after UV-irradiation are described. The caged non-hydrolyzable amino acids were incorporated into peptides by standard Fmoc solid-phase peptide synthesis, and the obtained peptides were successfully converted to the parent non-hydrolyzable phosphopeptides by UV-irradiation. Application of the caged non-hydrolyzable phosphoserine-containing peptide to photo-control the binding affinity of the peptide to 14-3-3β protein is also reported.
掲載誌名
Bioorganic & Medicinal Chemistry
ISSN
09680896
cat書誌ID
AA10938083
AA11522681
出版者
Elsevier Ltd.
22
11
開始ページ
2984
終了ページ
2991
発行日
2014-04-13
権利情報
© 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
薬学系