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ダウンロード数 : ?
ID 113736
著者
Ohte, Yuki University of Tokyo
Setoh, Kazuya Kyoto University
Nakase, Hiroshi University of Tokushima
前川, 明子 University of Tokushima
Kiyonari, Hiroshi RIKEN Center
Hamazaki, Yoko Kyoto University
Sekai, Miho Kyoto University
Sudo, Tetsuo Kyoto University
Tabara, Yasuharu Kyoto University
Sawai, Hiromi University of Tokyo
Omae, Yosuke University of Tokyo
Yuliwulandari, Rika YARSI University
Tanaka, Yasuhito Nagoya City University
Mizokami, Masashi National Center for Global Health and Medicine
井上, 寛 University of Tokushima
Kasahara, Masanori Hokkaido University
Minato, Nagahiro Kyoto University
Tokunaga, Katsushi University of Tokyo
Tanaka, Keiji Tokyo Metropolitan Institute of Medical Science
Matsuda, Fumihiko Kyoto University
Murata, Shigeo University of Tokyo
資料タイプ
学術雑誌論文
抄録
The Psmb11-encoded β5t subunit of the thymoproteasome, which is specifically expressed in cortical thymic epithelial cells (cTECs), is essential for the optimal positive selection of functionally competent CD8+ T cells in mice. Here, we report that a human genomic PSMB11 variation, which is detectable at an appreciable allele frequency in human populations, alters the β5t amino acid sequence that affects the processing of catalytically active β5t proteins. The introduction of this variation in the mouse genome revealed that the heterozygotes showed reduced β5t expression in cTECs and the homozygotes further exhibited reduction in the cellularity of CD8+ T cells. No severe health problems were noticed in many heterozygous and 5 homozygous human individuals. Long-term analysis of health status, particularly in the homozygotes, is expected to improve our understanding of the role of the thymoproteasome-dependent positive selection of CD8+ T cells in humans.
掲載誌名
JCI Insight
ISSN
23793708
出版者
American Society for Clinical Investigation
2
10
開始ページ
e93664
発行日
2017-05-18
権利情報
Open Access Journal
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
先端酵素学研究所