アクセス数 : ?
ダウンロード数 : ?
ID 66339
著者
佐田, 政隆 Department of Cardiovascular Medicine, Institute of Health Bioscience, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
福田, 大受 Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
atherosclerosis
renin-angiotensin system
reactive oxygen species
inflammation
資料タイプ
学術雑誌論文
抄録
The renin-angiotensin system (RAS) has been demonstrated to play a critical role in the initiation and progression of atherosclerosis, thereby contributing to development of cardiovascular diseases. Angiotensin II (Ang II), a major substrate in RAS, stimulates atherosclerosis through various deleterious effects such as endothelial dysfunction, cellular proliferation and inflammation. Recently, local RAS in vasculature is reported to play an important role. Many of these atherogenic actions of Ang II are mediated by reactive oxygen species (ROS). Investigation of the role of ROS and inflammation induced by RAS may provide a clue to understanding the pathophysiology of atherosclerotic diseases, and may lead to a new therapeutic strategy.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
57
1-2
開始ページ
12
終了ページ
25
並び順
12
発行日
2010-02
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
フルテキストファイル
言語
eng
部局
医学系