直近一年間の累計
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ID 115151
著者
Tomiyama, Hirofumi Tokyo Medical University
Ishizu, Tomoko University of Tsukuba
Kohro, Takahide Jichi Medical University
Matsumoto, Chisa Tokyo Medical University
Higashi, Yukihito Hiroshima University
Takase, Bonpei National Defense Medical College
Suzuki, Toru University of Leicester
Ueda, Shinichiro University of the Ryukyu
Yamazaki, Tsutomu The University of Tokyo
Furumoto, Tomoo Hokkaido University
Kario, Kazuomi Jichi Medical University
Inoue, Teruo Dokkyo Medical University
Koba, Shinji Showa University
Takemoto, Yasuhiko Osaka City University
Hano, Takuzo Wakayama Medical University
Ishibashi, Yutaka Shimane University
Node, Koichi Saga University
Maemura, Koji Nagasaki University
Ohya, Yusuke University of the Ryukyus
Furukawa, Taiji Teikyo University
Ito, Hiroshi Okayama University
Yamashina, Akira Tokyo Medical University
キーワード
Hypertension
Endothelial function
Arterial stiffness
Atherosclerosis
Renal function
資料タイプ
学術雑誌論文
抄録
Objectives: To examine the longitudinal mutual association between endothelial dysfunction and arterial stiffness, and also to determine which of the two variables was more closely associated with the progression of subclinical organ damage.
Methods: The brachial-ankle pulse wave velocity (baPWV), carotid intima-media thickness (CIMT), estimated glomerular filtration rate, microalbuminuria and flow-mediated vasodilatation of the brachial artery (FMD) were measured three times at 1.5-year intervals in 674 Japanese patients receiving antihypertensive treatment.
Results: The change of the baPWV during the study period was larger in the subjects with baseline FMD values in the lowest tertile as compared to those with baseline FMD values in the highest tertile. The change of the CIMT was smaller in the subjects with baseline baPWV values in the lowest tertile than in those with baseline baPWV values in the highest tertile. After the adjustment, the FMD value at the baseline was inversely associated with the baPWV at the end of the study period (beta = − 0.07, p = 0.01), although, the reverse association was not significant. The baPWV, but not the FMD value, at the baseline was associated with the CIMT (beta = 0.06, p = 0.04) measured at the end of the study period.
Conclusions: In hypertension, endothelial dysfunction was associated with the progression of arterial stiffness, although the reverse association was not confirmed. The increased arterial stiffness rather than endothelial dysfunction may be more closely associated with the progression of atherosclerotic vascular damage, and the endothelial dysfunction-arterial stiffness-atherosclerosis continuum may be important in hypertension.
掲載誌名
International Journal of Cardiology
ISSN
01675273
cat書誌ID
AA10623832
AA11530930
出版者
Elsevier
253
開始ページ
161
終了ページ
166
発行日
2017-11-12
権利情報
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系