中西, 信人 Tokushima University
堤, 理恵 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Hara, Kanako Tokushima University
Matsuo, Masafumi Kobe Gakuin University
阪上, 浩 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
大藤, 純 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
post-intensive care syndrome
Titin is a giant protein that functions as a molecular spring in sarcomeres. Titin interconnects the contraction of actin-containing thin filaments and myosin-containing thick filaments. Titin breaks down to form urinary titin N-fragments, which are measurable in urine. Urinary titin N-fragment was originally reported to be a useful biomarker in the diagnosis of muscle dystrophy. Recently, the urinary titin N-fragment has been increasingly gaining attention as a novel biomarker of muscle atrophy and intensive care unit-acquired weakness in critically ill patients, in whom titin loss is a possible pathophysiology. Furthermore, several studies have reported that the urinary titin N-fragment also reflected muscle atrophy and weakness in patients with chronic illnesses. It may be used to predict the risk of post-intensive care syndrome or to monitor patients’ condition after hospital discharge for better nutritional and rehabilitation management. We provide several tips on the use of this promising biomarker in post-intensive care syndrome.
Journal of Clinical Medicine
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
jcm_10_4_614.pdf 1.01 MB