直近一年間の累計
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ダウンロード数 : ?
ID 111634
著者
谷, 憲治 The University of Tokushima KAKEN研究者をさがす
Kashio, Makoto The University of Tokushima
佐野, 暢哉 The University of Tokushima
Nakamura, Yoichi The University of Tokushima
Ogushi, Fumitaka The University of Tokushima
キーワード
sarcoidosis
chronic eosinophilic pneumonia
cytokine
bronchoalveolar lavage
資料タイプ
学術雑誌論文
抄録
A 38-year-old man was hospitalized in our university hospital because of pulmonary opacities with bilateral hilar and mediastinal lymphadenopathy seen on chest radiograph. Eosinophilia was observed in the circulation and bronchoalveolar lavage (BAL) fluid. Histological examination revealed noncaseating epithelioid granulomas and eosinophilic infiltration in the lung. Based on these findings, a diagnosis of sarcoidosis combined with chronic eosinophilic pneumonia was made. The infiltrates on chest radiograph and BAL eosinophilia were promptly reduced with corticosteroid therapy, but only mild reduction was observed in diffuse nodular shadows and hilar and mediastinal lymphadenopathy, and high amounts of lymphocytes in BAL fluid remained. Increased IFN-γ, IL-4 and IL-5 were detected in the BAL fluid, and corticosteroid therapy reduced IL-4 and IL-5 (Th-2 cytokines) but not IFN-γ(Th-1 cytokine). These cytokine levels in BAL fluid were intimately correlated with the clinical course of sarcoidosis and chronic eosinophilic pneumonia.
掲載誌名
The Journal of Medical Investigation
ISSN
13431420
cat書誌ID
AA11166929
出版者
The University of Tokushima School of Medicine
45
1-4
開始ページ
131
終了ページ
136
並び順
131
発行日
1998-08
EDB ID
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系