ID 112458
タイトル別表記
8-PN promotes recovery from muscle atrophy via Akt pathway
著者
Horikawa, Hitomi Tokushima University
Lin, Pei-Yi Tokushima University
Tsukumo, Nao Tokushima University
Kawamura, Tomoyuki Tokushima University
キーワード
disuse muscle atrophy
8-prenylnaringenin
IGF1/PI3K/Akt pathway
phosphorylation
nutritional supplement
資料タイプ
学術雑誌論文
抄録
8-Prenylnaringenin (8-PN) is a prenylflavonoid that originates from hop extracts and is thought to help prevent disuse muscle atrophy. We hypothesized that 8-PN affects muscle plasticity by promoting muscle recovery under disuse muscle atrophy. To test the promoting effect of 8-PN on muscle recovery, we administered an 8-PN mixed diet to mice that had been immobilized with a cast to one leg for 14 days. Intake of the 8-PN mixed diet accelerated recovery from muscle atrophy, and prevented reductions in Akt phosphorylation. Studies on cell cultures of mouse myotubes in vitro demonstrated that 8-PN activated the PI3K/Akt/P70S6K1 pathway at physiologic concentrations. A cell-culture study using an inhibitor of estrogen receptors and an in vivo experiment with ovariectomized mice suggested that the estrogenic activity of 8-PN contributed to recovery from disuse muscle atrophy through activation of an Akt phosphorylation pathway. These data strongly suggest that 8-PN is a naturally occurring compound that could be used as a nutritional supplement to aid recovery from disuse muscle atrophy.
掲載誌名
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
ISSN
03636119
15221490
cat書誌ID
AA00521155
出版者
The American Physiological Society
311
6
開始ページ
R1022
終了ページ
R1031
発行日
2016-12-01
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
生物資源系
医学系
薬学系