| ID | 113581 |
| タイトル別表記 | MMP-13 Promotes Tumor Angiogenesis
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| 著者 |
Iizuka, Shinji
Hiroshima University
Yoshida, Maki
Hiroshima University
Subarnbhesaj, Ajiravudh
Hiroshima University
Deraz, Elsayed M.
Hiroshima University
Siriwardena, Samadarani B. S. M.
Hiroshima University
Tahara, Hidetoshi
Hiroshima University
Ogawa, Ikuko
Hiroshima University
高田, 隆
Hiroshima University
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| 資料タイプ |
学術雑誌論文
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| 抄録 | Background: Angiogenesis is an important step in the metastatic cascade of tumors.
Results: MMP-13 itself as well as VEGF-A secretion from fibroblasts promotes angiogenesis. Indeed, MMP-13 is well correlated with blood vessel density in human cancer tissues. Conclusion: MMP-13 can be a marker for prediction of malignant behaviors and a therapeutic target in cancer. Significance: This work provides new insights regarding the role of MMP-13 in tumor angiogenesis. |
| 掲載誌名 |
Journal of Biological Chemistry
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| ISSN | 1083351X
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| cat書誌ID | AA1202441X
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| 出版者 | The American Society for Biochemistry and Molecular Biology
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| 巻 | 287
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| 号 | 46
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| 開始ページ | 38716
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| 終了ページ | 38728
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| 発行日 | 2012-09-19
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| 備考 | This research was originally published in the Journal of Biological Chemistry. Yasusei Kudo, Shinji Iizuka, Maki Yoshida, Takaaki Tsunematsu, Tomoyuki Kondo, Ajiravudh Subarnbhesaj, Elsayed M. Deraz, Samadarani B. S. M. Siriwardena, Hidetoshi Tahara, Naozumi Ishimaru, Ikuko Ogawa, and Takashi Takata. Matrix Metalloproteinase-13 (MMP-13) Directly and Indirectly Promotes Tumor Angiogenesis. J. Biol. Chem. 2012; Vol:287(46) pp.38716-38728.
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| 権利情報 | © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.
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| EDB ID | |
| 出版社版DOI | |
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| フルテキストファイル | |
| 言語 |
eng
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| 著者版フラグ |
出版社版
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| 部局 |
歯学系
医学系
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