アクセス数 : ?
ダウンロード数 : ?
ID 110710
著者
カジモト, カズアキ Institute for Genome Research, The University of Tokushima
山﨑, 尚志 Faculty of Pharmaceutical Sciences, The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
片岡, 正俊 Institute for Genome Research, The University of Tokushima
寺田, 弘 Faculty of Pharmaceutical Sciences, Tokyo University of Science
篠原, 康雄 Institute for Genome Research, The University of Tokushima|Faculty of Pharmaceutical Sciences, The University of Tokushima|Single-Molecule Bioanalysis Laboratory, National Institute of Advanced Industrial Science and Technology (AIST) 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
brown adipose tissue
mitochondria
energy metabolism
uncoupling
資料タイプ
学術雑誌論文
抄録
Brown adipose tissue (BAT) is believed to function by dissipating excess energy in mammals. It is very important to understand the energy metabolism held in BAT since disorder of its energy-dissipating function may cause obesity or lifestyle-related diseases such as hypertension and diabetes. This function in BAT is mainly attributable to uncoupling protein (UCP), specifically expressed in its mitochondria. This protein consumes excess energy as heat by dissipating the H+ gradient across the inner mitochondrial membrane that is utilized as a driving force for ATP synthesis. In this review article, in addition to providing a brief introduction to the functional properties of BAT and UCP, we also describe and discuss properties of cultured brown adipocytes and the results of our exploratory studies on protein components involved in the energy-dissipating function in BAT.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
51
1-2
開始ページ
20
終了ページ
28
並び順
20
発行日
2004-02
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
薬学系
先端酵素学研究所