カジモト, カズアキ Institute for Genome Research, The University of Tokushima
片岡, 正俊 Institute for Genome Research, The University of Tokushima
寺田, 弘 Faculty of Pharmaceutical Sciences, Tokyo University of Science
brown adipose tissue
Brown adipose tissue (BAT) is believed to function by dissipating excess energy in mammals. It is very important to understand the energy metabolism held in BAT since disorder of its energy-dissipating function may cause obesity or lifestyle-related diseases such as hypertension and diabetes. This function in BAT is mainly attributable to uncoupling protein (UCP), specifically expressed in its mitochondria. This protein consumes excess energy as heat by dissipating the H+ gradient across the inner mitochondrial membrane that is utilized as a driving force for ATP synthesis. In this review article, in addition to providing a brief introduction to the functional properties of BAT and UCP, we also describe and discuss properties of cultured brown adipocytes and the results of our exploratory studies on protein components involved in the energy-dissipating function in BAT.
The journal of medical investigation : JMI
jmi_51_1-2_20.pdf 605 KB