ID 111338
著者
Koyama, Noriko Asahi University
Hayashi, Toru Asahi University
Gresik, Edward W The City University of New York Medical School
Kashimata, Masanori Asahi University
キーワード
α6 integrin
Branching morphogenesis
Cleft formation
Stalk elongation
Submandibular gland
資料タイプ
学術雑誌論文
抄録
The submandibular gland (SMG) of the fetal mouse is a well-studied model for the epithelial-mesenchymal interactions required for branching morphogenesis (BrM), which involves cleft formation and stalk elongation. In a previous report, we showed that α6 integrin subunit is involved in BrM of this gland rudiment, since the neutralizing antibody against α6 integrin subunit, GoH3, strongly inhibited branching of cultured intact E13 SMG. In this study, we investigated whether GoH3 inhibits cleft formation and/ or stalk elongation during BrM of cultured mesenchyme-free epithelial rudiments of fetal SMG and also analyzed by Western blotting the levels of phosphorylation of ERK1/2, which is a signaling molecule known to regulate BrM of the fetal mouse SMG.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
56
Supplement
開始ページ
247
終了ページ
249
並び順
247
発行日
2009-12
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版