アクセス数 : ?
ダウンロード数 : ?
ID 83939
著者
ナカタニ, ハジメ Department of Surgery, Kubokawa Hospital, Shimanto-cho
アキモリ, トヨカズ Department of General Surgery, Hatakenmin Hospital, Sukumo
タケザキ, ユカ Department of Surgery, Kochi Medical School, Kochi University
ハナザキ, カズヒロ Department of Surgery, Kochi Medical School, Kochi University
キーワード
esophagus
so-called carcinosarcoma
vascular endothelial growth factor
vascular endothelial growth factor receptor
資料タイプ
学術雑誌論文
抄録
Human carcinosarcomas of esophagus are uncommon malignant neoplasms that
are composed both carcinomatous and sarcomatous components. We established a novel
cell line, HN-Eso-1, from the metastatic esophageal spindle cell carcinoma (so-called carcinosarcoma).
In this study, we estimated the vascular endothelial growth factors (VEGFs)
and VEGF receptors (VEGFRs). Reverse transcription polymerase chain reaction (RTPCR)
studies revealed that VEGF-A,-C,-D and VEGFR-1,-2 were upregulated. Cisplatin
reduced the cell viability of HN-Eso-1 cells and VEGF attenuated its effect. These results
suggest that expression of VEGF-A, VEGF-C, VEGF-D, VEGFR-1, and VEGFR-2 are involved
in the cell’s autocrine system and that VEGF protected these cells from the antitumor
agent.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
57
3-4
開始ページ
232
終了ページ
236
並び順
232
発行日
2010-08
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
フルテキストファイル
言語
eng