| ID | 114103 |
| 著者 |
Ogawa, Masatoshi
Tokushima University
Zhou, Yu
Tokushima University
Tsuji, Ryosuke
Tokushima University
|
| キーワード | 6-OHDA
Mouse
Hind limb stepping
Hemi-parkinsonism
|
| 資料タイプ |
学術雑誌論文
|
| 抄録 | Unilateral injection of 6-hydroxydopamine (6-OHDA) is commonly used to generate a rodent model of Parkinson’s disease (PD). Although motor deficits of the lower extremities represent one of the major clinical symptoms in PD patients, validated tests for assessing motor impairments of the hind limb in 6-OHDA mice are currently unavailable. We here report the video-based assessments of the asymmetric use of hind limbs in 6-OHDA mice. A significantly decreased number of spontaneous hind limb stepping was observed in the contralateral-to-lesioned side, and was dose dependently reversed by levodopa, suggesting that it could be utilized for screening PD therapeutics.
|
| 掲載誌名 |
Neuroscience Research
|
| ISSN | 01680102
|
| cat書誌ID | AA10641652
AA11541052
|
| 出版者 | Elsevier
|
| 巻 | 154
|
| 開始ページ | 56
|
| 終了ページ | 59
|
| 発行日 | 2019-05-16
|
| 権利情報 | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
|
| EDB ID | |
| 出版社版DOI | |
| 出版社版URL | |
| フルテキストファイル |
neures_154_56_suppl_video1.mp4
5.16 MB
neures_154_56_suppl_video2.mp4
8.04 MB
neures_154_56_suppl_video3.mp4
9.31 MB
|
| 言語 |
eng
|
| 著者版フラグ |
著者版
|
| 部局 |
医学系
薬学系
|
