ID 111907
Author
Hirakawa, Hiroko The University of Tokushima
Yamamoto, Jun The University of Tokushima
Ogura, Keiji The University of Tokushima
Denda, Masaya The University of Tokushima
Yamaguchi, Keiko The University of Tokushima
Keywords
Amide bond cleavage
Caged compound
Ceramide
Sphingolipid
UV-responsive
Content Type
Journal Article
Description
Sphingolipids, recognized as membrane constructs and as key signaling molecules, have been studied to examine intracellular function. Some caged sphingolipids that release parent sphingolipids after exposure to UV-irradiation have been previously developed, but caged ceramide has yet to be reported. In this study, we report the design and synthesis of a caged ceramide. Photo-irradiation experiment clarified that the caged ceramide can be successfully converted to the parent ceramide by UV-irradiation. Introduction of an alkyne-handle moiety for further modification of the caged ceramide is also reported.
Journal Title
Tetrahedron
ISSN
00404020
NCID
AA00861787
AA11539786
Publisher
Elsevier Ltd.
Volume
67
Issue
22
Start Page
3984
End Page
3990
Published Date
2011-04-20
Rights
© 2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Pharmaceutical Sciences