ID 111907
著者
Hirakawa, Hiroko The University of Tokushima
Yamamoto, Jun The University of Tokushima
Ogura, Keiji The University of Tokushima
Denda, Masaya The University of Tokushima
Yamaguchi, Keiko The University of Tokushima
キーワード
Amide bond cleavage
Caged compound
Ceramide
Sphingolipid
UV-responsive
資料タイプ
学術雑誌論文
抄録
Sphingolipids, recognized as membrane constructs and as key signaling molecules, have been studied to examine intracellular function. Some caged sphingolipids that release parent sphingolipids after exposure to UV-irradiation have been previously developed, but caged ceramide has yet to be reported. In this study, we report the design and synthesis of a caged ceramide. Photo-irradiation experiment clarified that the caged ceramide can be successfully converted to the parent ceramide by UV-irradiation. Introduction of an alkyne-handle moiety for further modification of the caged ceramide is also reported.
掲載誌名
Tetrahedron
ISSN
00404020
cat書誌ID
AA00861787
AA11539786
出版者
Elsevier Ltd.
67
22
開始ページ
3984
終了ページ
3990
発行日
2011-04-20
権利情報
© 2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
薬学系