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Otaka, Akira

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Labelling of Endogenous Target Protein via N–S Acyl Transfer-Mediated Activation of N-Sulfanylethylanilide
Author Denda, Masaya/ Morisaki, Takuya/ Kohiki, Taiki/ Yamamoto, Jun/ Sato, Kohei/ Sagawa, Ikuko/ Inokuma, Tsubasa/ Sato, Youichi/ Yamauchi, Aiko/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic & Biomolecular Chemistry
Volume 14
Issue 26
Published Date 2016-05-31
departments Technical Support Department Pharmaceutical Sciences
Development of a fluoride-responsive amide bond cleavage device that is potentially applicable to a traceable linker
Author Yamamoto, Jun/ Maeda, Nami/ Komiya, Chiaki/ Tanaka, Tomohiro/ Denda, Masaya/ Ebisuno, Koji/ Nomura, Wataru/ Tamamura, Hirokazu/ Sato, Youichi/ Yamauchi, Aiko/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Tetrahedron
Volume 70
Issue 34
Published Date 2014-06-06
departments Pharmaceutical Sciences
Development of caged non-hydrolyzable phosphoamino acids and application to photo-control of binding affinity of phosphopeptide mimetic to phosphopeptide-recognizing protein
Author Ebisuno, Koji/ Denda, Masaya/ Ogura, Keiji/ Inokuma, Tsubasa/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Bioorganic & Medicinal Chemistry
Volume 22
Issue 11
Published Date 2014-04-13
departments Pharmaceutical Sciences
Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins
Author Yamamoto, Jun/ Denda, Masaya/ Maeda, Nami/ Kita, Miku/ Komiya, Chiaki/ Tanaka, Tomohiro/ Nomura, Wataru/ Tamamura, Hirokazu/ Sato, Youichi/ Yamauchi, Aiko/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic & Biomolecular Chemistry
Volume 12
Issue 23
Published Date 2014-04-17
departments Pharmaceutical Sciences
An N-sulfanylethylanilide-based traceable linker for enrichment and selective labelling of target proteins
Author Morisaki, Takuya/ Denda, Masaya/ Yamamoto, Jun/ Tsuji, Daisuke/ Inokuma, Tsubasa/ Itoh, Kohji/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemical Communications
Volume 52
Issue 42
Published Date 2016-04-26
departments Pharmaceutical Sciences
Elucidation of inhibitor-binding pockets of D-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology
Author Kohiki, Taiki/ Kato, Yusuke/ Nishikawa, Yusuke/ Yorita, Kazuko/ Sagawa, Ikuko/ Denda, Masaya/ Inokuma, Tsubasa/ Shigenaga, Akira/ Fukui, Kiyoshi/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic & Biomolecular Chemistry
Volume 15
Issue 25
Published Date 2017-05-05
departments Institute of Advanced Medical Sciences Technical Support Department Pharmaceutical Sciences
Advanced Insulin Synthesis by One-pot/Stepwise Disulfide Bond Formation Enabled by S-Protected Cysteine Sulfoxide
Author Hidaka, Kota/ Kobayashi, Daishiro/ Hayashi, Junya/ Denda, Masaya/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemistry- A European Journal
Volume 30
Issue 39
Published Date 2024-04-29
departments Pharmaceutical Sciences
Sulfanylmethyldimethylaminopyridine as a Useful Thiol Additive for Ligation Chemistry in Peptide/Protein Synthesis
Author Ohkawachi, Kento/ Kobayashi, Daishiro/ Morimoto, Kyohei/ Shigenaga, Akira/ Denda, Masaya/ Yamatsugu, Kenzo/ Kanai, Motomu/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic Letters
Volume 22
Issue 14
Published Date 2020-05-12
departments Pharmaceutical Sciences
Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics
Author Yoshimaru, Tetsuro/ Aihara, Keisuke/ Komatsu, Masato/ Matsushita, Yosuke/ Okazaki, Yasumasa/ Toyokuni, Shinya/ Honda, Junko/ Sasa, Mitsunori/ Miyoshi, Yasuo/ Otaka, Akira/ Katagiri, Toyomasa/
Content Type Journal Article
Journal Title Scientific Reports
Volume 7
Published Date 2017-05-12
departments Institute of Advanced Medical Sciences Pharmaceutical Sciences
Traceless synthesis of protein thioesters using enzyme-mediated hydrazinolysis and subsequent self-editing of cysteinyl prolyl sequence
Author Komiya, Chiaki/ Shigenaga, Akira/ Tsukimoto, Jun/ Ueda, Masahiro/ Morisaki, Takuya/ Inokuma, Tsubasa/ Itoh, Kohji/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemical Communications
Volume 55
Issue 49
Published Date 2019-05-23
departments Pharmaceutical Sciences
磁気浮上を利用した簡便な固相反応モニター法の開発
Author Shigenaga, Akira/ Otaka, Akira/
Content Type Others
Journal Title Chemical Biology
Volume 2
Issue 2
Published Date 2009-05-18
departments Pharmaceutical Sciences
Deprotection of S-Acetamidomethyl Cysteine with Copper (II) and 1,2-Aminothiols under Aerobic Conditions
Author Kobayashi, Daishiro/ Naruse, Naoto/ Denda, Masaya/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic & Biomolecular Chemistry
Volume 18
Issue 42
Published Date 2020-08-20
departments Pharmaceutical Sciences
Development of a 1,3a,6a-triazapentalene derivative as a compact and thiol-specific fluorescent labeling reagent
Author Nakayama, Atsushi/ Otani, Akira/ Inokuma, Tsubasa/ Tsuji, Daisuke/ Mukaiyama, Haruka/ Nakayama, Akira/ Itoh, Kohji/ Otaka, Akira/ Tanino, Keiji/ Namba, Kosuke/
Content Type Journal Article
Journal Title Communications Chemistry
Volume 3
Published Date 2020-01-09
departments Pharmaceutical Sciences
Development of an Anilide-Type Scaffold for the Thioester Precursor N-Sulfanylethylcoumarinyl Amide
Author Eto, Mitsuhiro/ Naruse, Naoto/ Morimoto, Kyohei/ Yamaoka, Kosuke/ Sato, Kohei/ Tsuji, Kohei/ Inokuma, Tsubasa/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic Letters
Volume 18
Issue 17
Published Date 2016-08-16
departments Pharmaceutical Sciences
Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues that Allows Facile Access to Protein Library
Author Nakamura, Takahiro/ Sato, Kohei/ Naruse, Naoto/ Kitakaze, Keisuke/ Inokuma, Tsubasa/ Hirokawa, Takatsugu/ Shigenaga, Akira/ Itoh, Kohji/ Otaka, Akira/
Content Type Journal Article
Journal Title ChemBioChem
Volume 17
Issue 20
Published Date 2016-08-19
departments Pharmaceutical Sciences
The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate
Author Sato, Kohei/ Kitakaze, Keisuke/ Nakamura, Takahiro/ Naruse, Naoto/ Aihara, Keisuke/ Shigenaga, Akira/ Inokuma, Tsubasa/ Tsuji, Daisuke/ Itoh, Kohji/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemical Communications
Volume 51
Issue 49
Published Date 2015-05-13
departments Pharmaceutical Sciences
Synthesis of lactam-bridged cyclic peptides using sequential olefin metathesis and diimide reduction reactions
Author Aihara, Keisuke/ Inokuma, Tsubasa/ Komiya, Chiaki/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Tetrahedron
Volume 71
Issue 24
Published Date 2015-05-01
departments Pharmaceutical Sciences
Cysteine-Free Intramolecular Ligation of N-Sulfanylethylanilide Peptide Using 4-Mercaptobenzylphosphonic Acid : Synthesis of Cyclic Peptide Trichamide
Author Aihara, Keisuke/ Inokuma, Tsubasa/ Jichu, Takahisa/ Lin, Zhenjian/ Fu, Feixue/ Yamaoka, Kosuke/ Shigenaga, Akira/ Hutchins, David A./ Schmidt, Eric W./ Otaka, Akira/
Content Type Journal Article
Journal Title Synlett
Volume 28
Issue 15
Published Date 2017-07-06
departments Pharmaceutical Sciences
Resin-Bound Crypto-Thioester for Native Chemical Ligation
Author Naruse, Naoto/ Ohkawachi, Kento/ Inokuma, Tsubasa/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic Letters
Volume 20
Issue 8
Published Date 2018-04-09
departments Pharmaceutical Sciences
Development of a Chemical Methodology for the Preparation of Peptide Thioesters Applicable to Naturally Occurring Peptides Using a Sequential Quadruple Acyl Transfer System
Author Tsuda, Yusuke/ Shigenaga, Akira/ Tsuji, Kohei/ Denda, Masaya/ Sato, Kohei/ Kitakaze, Keisuke/ Nakamura, Takahiro/ Inokuma, Tsubasa/ Itoh, Kohji/ Otaka, Akira/
Content Type Journal Article
Journal Title ChemistryOpen
Volume 4
Issue 4
Published Date 2015-04-28
departments Pharmaceutical Sciences
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