| ID | 111902 |
| 著者 |
Yamamoto, Jun
The University of Tokushima
Hirakawa, Hiroko
The University of Tokushima
Yamaguchi, Keiko
The University of Tokushima
|
| キーワード | FRET
Stimulus responsive
Peptide bond cleavage
UV irradiation
|
| 資料タイプ |
学術雑誌論文
|
| 抄録 | In the field of chemical biology, methods for controlling peptidyl function by a stimulus are attracting increasing attention. Recently, we reported a stimulus-responsive peptide which can be cleaved after exposure to a stimulus. In this study, we developed a FRET-based assay system to estimate the kinetics of the stimulus-induced processing (peptide bond cleavage) reaction. Based on the FRET system, it was clarified that introduction of a sterically less-hindered or polar residue at the position adjacent to the stimulus-responsive amino acid accelerates the processing reaction.
|
| 掲載誌名 |
Tetrahedron
|
| ISSN | 00404020
|
| cat書誌ID | AA00861787
AA11539786
|
| 出版者 | Elsevier Ltd.
|
| 巻 | 65
|
| 号 | 11
|
| 開始ページ | 2212
|
| 終了ページ | 2216
|
| 発行日 | 2009-01-20
|
| 権利情報 | ©2009. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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| EDB ID | |
| 出版社版DOI | |
| 出版社版URL | |
| フルテキストファイル | |
| 言語 |
eng
|
| 著者版フラグ |
著者版
|
| 部局 |
薬学系
|
